Drug Interactions in Infectious Diseases 3rd Edition

Drug Interactions in Infectious Diseases, 3rd Edition is a comprehensive reference dedicated to the complex interactions associated with antimicrobial medications, infectious diseases, and inflammation. The book examines the mechanisms, clinical risks, and consequences of drug interactions while providing practical information that can help healthcare professionals recognize and manage these challenges.

This revised edition expands its coverage with new chapters addressing drug interactions involving non-HIV antiviral, antimalarial, antiparasitic, antihelmintic, macrolide, azalide, and ketolide agents. It also introduces important material on probe-cocktail studies, drug-cytokine interactions, regulatory considerations, and the design and analysis of drug interaction studies.

About the Book

Drug interactions can significantly affect the effectiveness and safety of antimicrobial therapy. Understanding these interactions requires knowledge of pharmacological mechanisms as well as the effects of infection and inflammation on drug disposition and response.

This edition brings together clinically relevant information in a single reference, with detailed discussions of interaction mechanisms and practical strategies for managing potential problems. Informative tables throughout the book provide a convenient way to review specific drug-drug interactions and their degree of clinical significance.

Key Topics Covered

Antimicrobial Drug Interactions

The book provides extensive coverage of interactions involving antimicrobial agents, making it a valuable reference for understanding how different anti-infective therapies may interact with other medications.

New Antiviral and Antiparasitic Coverage

Five new chapters expand the scope of the third edition. These include interactions involving non-HIV antiviral, antimalarial, antiparasitic, and antihelmintic drugs, as well as macrolide, azalide, and ketolide agents.

Mechanisms of Drug Interactions

In-depth discussions explore the potential mechanisms and pathways responsible for drug interactions. Understanding these mechanisms helps clinicians and researchers evaluate potential risks and consider appropriate management strategies.

Drug-Food Interactions

The book retains its detailed coverage of drug-food interactions, providing information that is particularly relevant when dietary factors can alter the effects or handling of antimicrobial medications.

Drug-Cytokine Interactions

A newly written perspective on drug-cytokine interactions highlights the complex relationship between acute infection, inflammation, and the risk of drug interactions. This section emphasizes the importance of considering physiological changes associated with infection when evaluating medication interactions.

Probe-Cocktail Studies

A new chapter introduces probe-cocktail studies as an important research tool for investigating drug-drug interactions and supporting drug development.

Study Design and Analysis

The book includes authoritative discussions of study design and analytical approaches used in drug interaction research, making it relevant not only to clinicians but also to researchers involved in pharmacological studies.

Regulatory Considerations

Regulatory aspects of drug interactions during drug development are also addressed, providing additional context for researchers and professionals involved in pharmaceutical development.

Quick Clinical Reference

Informative tables throughout the chapters summarize specific drug-drug interactions and their degree of interaction. These tables make it easier to locate clinically relevant information without having to read the entire discussion, making the book useful as both a detailed reference and a quick clinical resource.

Who Should Use This Book?

• Infectious disease physicians and specialists
• Clinical pharmacists and pharmacy students
• Physicians and healthcare professionals prescribing antimicrobial therapy
• Pharmacologists and researchers studying drug interactions
• Medical and postgraduate students studying infectious diseases
• Researchers involved in drug development and pharmacology
• Healthcare professionals interested in antimicrobial safety and therapeutic management

Final Thoughts

Drug Interactions in Infectious Diseases, 3rd Edition brings together extensive information on the interactions between antimicrobial drugs, other medications, food, cytokines, infection, and inflammation. Its combination of mechanistic explanations, clinical tables, new antimicrobial coverage, and research-focused chapters makes it a valuable reference for both clinical practice and academic study.

The third edition is particularly useful for readers who need to understand not only which interactions may occur, but also the mechanisms behind them and the strategies that can be used to evaluate and manage their potential consequences.

Book Information

Title: Drug Interactions in Infectious Diseases
Publisher: Humana
Publication Date: September 8, 2011
Edition: 3rd
Language: English
Print Length: 1321 pages
ISBN-13: 978-1617792137
ASIN: B00F5V3SLC
Subjects: Drug Interactions, Infectious Diseases, Antimicrobial Therapy, Clinical Pharmacology, Antimicrobial Pharmacology, Drug-Drug Interactions, Drug-Food Interactions, Drug-Cytokine Interactions, Pharmacology, Infectious Disease Pharmacology, Drug Development

Drug Interactions in Infectious Diseases, 3rd Edition is a comprehensive reference on antimicrobial drug interactions, their mechanisms and clinical consequences, and strategies for evaluating and managing interaction risks.